TABLE 2.
Overall and Breast Cancer-Specific Mortality Associations of Vitamin D Status in Breast Cancer Survivors
| Models of association of vitamin D status and death from any cause | Serum 25(OH)D | |||||||
|---|---|---|---|---|---|---|---|---|
| Continuous per 10 ng/mL (N=585)
|
Deficient <20 ng/mL (N=211)
|
Insufficient 20–30 ng/mL (N=189)
|
Sufficient >30 ng/mL (N=185)
|
|||||
| HR (95% CI) | Ptrend | HR | (95%CI) | HR | (95% CI) | HR | (95% CI) | |
| Death, any cause | 43 deaths | 41 deaths | 26 deaths | |||||
| Unadjusted | 0.74 (0.60 – 0.91) | <0.01 | 1.00 | - | 0.83 | (0.53 – 1.29) | 0.58 | (0.35 – 0.95) |
| Age-adjusteda | 0.74 (0.60 – 0.92) | <0.01 | 1.00 | - | 0.84 | (0.54 – 1.31) | 0.58 | (0.36 – 0.96) |
| Multivariateb,c | 0.85 (0.68 – 1.09) | 0.20 | 1.00 | - | 1.07 | (0.66 – 1.75) | 0.90 | (0.50 – 1.61) |
| Death, breast cancer-specific cause | 22 events | 14 events | 12 events | |||||
| Unadjusted | 0.80 (0.59 – 1.09) | 0.15 | 1.00 | - | 0.75 | (0.38 –1.48) | 0.62 | (0.31 – 1.27) |
| Age-adjusteda | 0.80 (0.59 – 1.09) | 0.15 | 1.00 | - | 0.75 | (0.38 – 1.48) | 0.62 | (0.31 –1.27) |
| Multivariateb | 1.08 (0.75 – 1.54) | 0.68 | 1.00 | - | 1.12 | (0.54 – 2.33) | 1.21 | (0.52 – 2.80) |
Abbreviation: HR, hazard ratio; 95% CI, 95 percent confidence interval
Ptrend was calculated by using serum 25(OH)D as a continuous variable
a
Model adjusted solely for age at diagnosis
b
Models adjusted for age at diagnosis, tumor stage, body mass index categories, race-ethnicity/study site, Tamoxifen use, season of blood draw and treatment used
c
Additional adjustment for physical activity and smoking status