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Thrombin generation assay. Thrombin generation assays were performed in the presence of 0.25 nM FVIII WT or variant, 0.5 pM rTF, and 4 μM PSPCPE vesicles. Data represent the average values of triplicate samples. Representative thrombograms of WT (black dotted line), Gly1750Cys/Arg2116Cys (black solid line), Ala1866Cys/Ser2119Cys (grey dotted line), and Ser2029Cys/Pro2292Cys (grey solid line), and a negative control (0 nM FVIII, black alternate dash and dot line) are shown.
