TABLE 2.
Characteristics of hepatitis C virus (HCV) patients
|
HCV group (n=60)
|
|||
|---|---|---|---|
| Characteristics | Group 1a (responders [n=38]) | Group 1b (nonresponders [n=22])) | P |
| Age, years | 38.6 ±0.8 | 39.3 ±10.9 | 0.573 |
| Sex, male/female, n/n | 23/15 | 13/9 | – |
| Body mass index, kg/m2 | 22.8±11.35 | 23.3±5.11 | 0.846 |
| AST, U/L | 50.91±11.15 | 53.5±11.6 | 0.401 |
| ALT, U/L | 55.05±13.07 | 64.79±14.62 | 0.012* |
| Albumin, g/L | 39.0±13.0 | 38.0±6.0 | 0.735 |
| Total bilirubin, mg/dL | 18.81±1.7 | 20.52±6.84 | 0.146 |
| Viral load, ×105 | 7.37±8.06 | 6.3±6.06 | 0.562 |
| Histological finding | |||
| Activity score | 4.0±1.81 | 4.1± 2.86 | 0.869 |
| Fibrosis score | 1.8±0.77 | 2.2±0.8 | 0.061 |
| STAT1 | 411.9±77.5 | 405.5±40.37 | 0.747 |
| STAT1-phosphorylated | 281±80.8 | 91.95±46.46 | 0.001* |
| PIAS1 | 142.0±52.41 | 712.7±158.8 | 0.001* |
| SOCS3 | 45.82±16.43 | 358.7±111.8 | 0.001* |
Data presented as mean ± SD unless otherwise indicated.
*
Statistically significant (ie, P<0.05). ALT Alanine aminotransferase; AST Aspartate aminotransferase; BMI Body mass index; PIAS Protein inhibitor of activated suppressor of cytokine signalling (STAT); SOCS Suppressor of cytokine signalling