Table 3.

Odds ratios (95% confidence intervals) for dementia and cognitive impairment after 25 years according to midlife caffeine intake

	Caffeine intake (mg/d)
	0–115.5	>115.5–188.0	>188.0–277.5	>277.5–415.0	>415.0–2673.0
No. of men	707	604	784	704	695
All dementia
No. of cases	43	42	51	54	36
Age-adjusted	1.00	1.13 (0.71–1.80)	1.26 (0.81–1.96)	1.46 (0.94–2.26)	1.25 (0.77–2.03)
Multivariable-adjusted*	1.00	1.21 (0.74–1.96)	1.31 (0.82–2.09)	1.47 (0.92–2.35)	1.12 (0.66–1.91)
Alzheimer's disease
No. of cases	26	24	26	24	18
Age-adjusted	1.00	1.05 (0.58–1.90)	1.05 (0.59–1.87)	1.03 (0.57–1.86)	1.08 (0.57–2.03)
Multivariable-adjusted*	1.00	1.20 (0.65–2.23)	1.15 (0.62–2.11)	1.07 (0.57–2.00)	0.95 (0.46–1.95)
Vascular dementia
No. of cases	11	15	19	22	13
Age-adjusted	1.00	1.59 (0.71–3.52)	1.82 (0.85–3.89)	2.28 (1.08–4.81)	1.74 (0.76–3.98)
Multivariable-adjusted*	1.00	1.52 (0.68–3.43)	1.83 (0.84–3.99)	2.09 (0.97–4.52)	1.45 (0.59–3.53)
Cognitive impairment (CASI <74)
No. of cases	67	69	77	80	54
Age-adjusted	1.00	1.22 (0.83–1.78)	1.19 (0.82–1.72)	1.37 (0.95–1.97)	1.13 (0.76–1.69)
Multivariable-adjusted*	1.00	1.20 (0.80–1.80)	1.21 (0.82–1.79)	1.33 (0.90–1.98)	1.02 (0.66–1.59)

^*Adjusts for age, physical activity index, smoking, years of education, APOE ε4 status, elevated cholesterol, and hypertension.