Table 5.

Odds ratios (95% confidence intervals) for brain pathology according to midlife caffeine intake among 418 decedents, 1992–2004

	Caffeine intake, quartiles (mg/d)
	0–137.0	138.5–231.0	251.5–391.5	411.0–1872.5
No. of men	109	99	105	105
Alzheimer lesions
No. of cases	27	25	25	26
Age-adjusted	1.00	1.00 (0.53–1.90)	0.98 (0.52–1.84)	1.03 (0.55–1.93)
Multivariable-adjusted*	1.00	1.10 (0.55–2.18)	0.96 (0.48–1.90)	0.85 (0.42–1.73)
Microvascular ischemic lesions
No. of cases	43	46	31	34
Age-adjusted	1.00	1.31 (0.75–2.27)	0.64 (0.36–1.12)	0.73 (0.42–1.28)
Multivariable-adjusted*	1.00	1.27 (0.72–2.26)	0.66 (0.37–1.20)	0.79 (0.43–1.45)
Generalized atrophy
No. of cases	54	40	46	48
Age-adjusted	1.00	0.66 (0.37–1.16)	0.80 (0.46–1.40)	0.87 (0.50–1.52)
Multivariable-adjusted*	1.00	0.68 (0.38–1.22)	0.87 (0.49–1.55)	1.01 (0.56–1.84)
Cortical Lewy bodies
No. of cases	19	14	18	12
Age-adjusted	1.00	0.76 (0.36–1.62)	0.99 (0.49–2.03)	0.62 (0.28–1.36)
Multivariable-adjusted*	1.00	0.82 (0.38–1.80)	1.10 (0.52–2.31)	0.71 (0.30–1.66)
Hippocampal sclerosis
No. of cases	13	9	8	8
Age-adjusted	1.00	0.71 (0.29–1.77)	0.61 (0.24–1.56)	0.63 (0.25–1.60)
Multivariable-adjusted*	1.00	0.67 (0.25–1.78)	0.62 (0.23–1.71)	0.77 (0.27–2.20)
Any lesions
No. of cases	87	70	71	68
Age-adjusted	1.00	0.59 (0.31–1.12)	0.53 (0.28–1.00)	0.46 (0.25–0.86)
Multivariable-adjusted*	1.00	0.61 (0.31–1.20)	0.57 (0.30–1.10)	0.45 (0.23–0.89)

^*Adjusts for age at death, physical activity index, smoking, years of education, APOE ε4 status, elevated cholesterol, and hypertension. LRT p, trend=0.04 for any lesions.