Table 1.

Mtb Dxr IC₅₀ values and GScores of amide and O-linked ligands

compd	R1	R2	IC50 (µM)
1	H	H	0.3116
2	H	CH3	2.39
3	(CH2)2Ph	CH3	(81.5)*
4	(CH2)3Ph	CH3	(77.5)*
5	4-ipr-benzyl	CH3	48.4
6	CH2cyclohexyl	CH3	(83.5)*
7	H	CH2Ph	26.9
8	H	(CH2)3Ph	17.8
9	H	cyclohexyl	(80.0)*

^*Values in parentheses are percent remaining enzyme activity at 100 µM.