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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Adv Chem Phys. 2012 Jan 31;150:255–326. doi: 10.1002/9781118197714.ch6

Fig. 25.

Fig. 25

Characterization of prion denatured state with SGLD simulations (Lee & Chang 2010). (A) The NMR structure of huPrP121–231 (PDB 1hjn [19]), (B) fully unfolded huPrP 121–230 at 600 K with the disulfide-bond shown in red, and (C) the simulated denatured structure of huPrP from the most populated cluster. The helical regions I, II and III defined based on the native structure are colored in red, blue and magentas, respectively.