Table 2.

Serum levels of specific vitamin D measurements at baseline and after 6 months of treatment.

Analvte Treatment Group	Baseline			6-month Follow-up			Absolute Rx Effect^b		Proportional Rx Effect^c (%)

	N	Mean (SE)^a	P^d	N	Mean (SE)^a	P^d	Mean (SE)^a	P^d
25(OH)D₃ (ng/mL)
Placebo	20	18.8 (1.9)		21	17.2 (1.9)		0		-
Calcium	21	23.4 (1.9)	0.10	21	22.5 (2.0)	0.06	0.8 (2.5)	0.74	3.4
Vitamin D₃	21	19.4 (1.9)	0.84	21	28.3 (2.0)	0.0001	10.7 (2.4)	<0.0001	55.2
Calcium + Vitamin D₃	21	18.8 (1.9)	0.98	18	26.0 (2.0)	0.002	9.0 (2.5)	0.0005	47.9
25(OH)D₂ (ng/mL)
Placebo	20	2.5 (1.3)		21	2.4 (1.3)		0		-
Calcium	21	1.9 (1.3)	0.76	21	2.1 (1.4)	0.89	0.3 (1.0)	0.75	15.8
Vitamin D₃	21	2.3 (1.3)	0.93	21	1.2 (1.3)	0.52	−1.1 (1.0)	0.26	−47.8
Calcium + Vitamin D₃	21	4.3 (1.3)	0.35	18	3.3 (1.4)	0.64	−0.9 (1.0)	0.36	−20.9
Vitamin D₃ (ng/mL)
Placebo	20	13.2 (1.5)		21	12.3 (1.6)		0		-
Calcium	21	12.7 (1.5)	0.78	21	12.7(1.7)	0.87	0.9 (2.4)	0.70	7.1
Vitamin D₃	21	12.5 (1.5)	0.81	21	15.8(1.6)	0.12	4.2 (2.3)	0.08	33.6
Calcium + Vitamin D₃	21	12.6 (1.5)	0.76	18	13.8 (1.6)	0.50	2.1 (2.3)	0.36	16.7
Vitamin D₂ (ng/mL)
Placebo	20	0.44 (0.16)		21	0.42 (0.16)		0		-
Calcium	21	0.31 (0.16)	0.56	21	0.34 (0.17)	0.74	0.06 (0.19)	0.77	19.4
Vitamin D₃	21	0.64 (0.16)	0.39	21	0.54 (0.17)	0.60	−0.08 (0.19)	0.68	−12.5
Calcium + Vitamin D₃	21	0.49 (0.16)	0.84	18	0.45 (0.17)	0.91	−0.02 (0.19)	0.91	−4.1

Least-squares means are used.

Absolute treatment (Rx) effect = [(treatment group follow-up) – (treatment group baseline)] – [(placebo group follow-up) – (placebo group baseline)].

Proportional treatment (Rx) effect = (absolute treatment effect / treatment group baseline) × 100% (e.g., a proportional effect of 55% would mean that a 55% increase in the active treatment group relative to the placebo group).

P value for difference between each active treatment group and the placebo group from repeated measures MIXED model.