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. 2013 Aug 1;9(8):e1003632. doi: 10.1371/journal.pgen.1003632

Figure 3. Lyso-Gb3 values for female and male Fabry patients compared to control.

Figure 3

The horizontal mark indicated the median. It is noteworthy that lyso-Gb3 levels in males are ∼10 times higher than in females. Each data point represents one patient. Indicated in pink are patients with the mutation p.S126G (8f/4m), in blue p.A143T (10f/8m) and in green p.D313Y (33f/24m) to illustrate that most found non-pathogenic mutations belong to either one or the other patient cohort. Other exceptions are: p.R118C, p.V316I, p.E418G (one male patient each) and p.A20P, p.D83N, p.I91T, p.S102L, p.R112C, p.R118C, p.D175E, p.G325S, p.A368T, p.T385A, p.W399*, c.1208delT, p.L415F, (one female patient each) and p.R252T (4×), p.N215S (3×). About 180 healthy probands were tested with no Fabry gene variation and had values of 0.9 ng/ml (95th percentile calculation).