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. 2013 Aug 1;9(8):e1003649. doi: 10.1371/journal.pgen.1003649

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© 2013 Brown et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A, B, C) eQTL replication frequency (y-axis) as a function of discovery significance (x-axis: ). SNPs were grouped into 30 equally spaced bins by BF. (D, E, F) eQTL replication frequency (y-axis; thresholded at ) as a function of SNP position () (x-axis). Cis-eQTL SNPs within 250 kb of the TSS were grouped into equally spaced bins. (A, D) Replication frequencies for CAP_LCL eQTLs in Stranger_LCLs (blue) and Merck_liver (red). (B, E) Replication frequencies for UChicago_liver eQTLs in Merck_liver (blue) and Stranger_LCL (red). (C, F) Replication frequencies for Myers_brain eQTLs in Harvard_cerebellum (blue) and Stranger_LCL (red). In all panels, bold lines depict percentage of SNP-gene pairs with per bin, and ribbons depict confidence interval.

Inline graphic — (A, B, C) eQTL replication frequency (y-axis) as a function of discovery significance (x-axis: ). SNPs were grouped into 30 equally spaced bins by BF. (D, E, F) eQTL replication frequency (y-axis; thresholded at ) as a function of SNP position () (x-axis). Cis-eQTL SNPs within 250 kb of the TSS were grouped into equally spaced bins. (A, D) Replication frequencies for CAP_LCL eQTLs in Stranger_LCLs (blue) and Merck_liver (red). (B, E) Replication frequencies for UChicago_liver eQTLs in Merck_liver (blue) and Stranger_LCL (red). (C, F) Replication frequencies for Myers_brain eQTLs in Harvard_cerebellum (blue) and Stranger_LCL (red). In all panels, bold lines depict percentage of SNP-gene pairs with per bin, and ribbons depict confidence interval.