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Mice were subcutaneously infected with 2×107 CFU S. pyogenes bacteria and plasma samples were collected at 0, 24, 30, 42 and 48 hours after infection (n = 5–11/group). Tissue factor activity (A) and pro-coagulant MVs (B) expressed as PS equivalent (nM) were measured. *P<0.05, ***P<0.0001.
