Figure 2. AAV-D76A reduces expression of MAC-3 and VCAM-1 in aortic lesions.

Sections adjacent to the sinus of the aortic roots were immuno-stained using antibodies against (A) CD107b (MAC-3), a marker of macrophage infiltration, and (B) vascular cell adhesion molecule (VCAM-1), an endothelial ligand that promotes the adhesion of lymphocytes, monocytes, eosinophils, and basophils (EC: endothelial cells, VW: vessel wall, LC: lipid core). Lower panels display the quantitative analyses of immunostaining determined by densitometry (mean±SEM, n = 5).