Table 2. ART initiation during the chronic stage of HIV infection according to calendar period following changes in recommendations based on clinical stage and CD4 count; the ANRS PRIMO and COPANA cohorts.

	Period of observation	Criteria for initiation
		Present at enrollment	Occurring during follow-up	p-value*
	2005–2008	CD4<200 or clinical AIDS
		N = 113	N = 65
ART initiation, % (n )**		96.5 (109)	84.6 (55)	0.005
	2009–2010	CD4<350 or clinical AIDS
			N = 86
ART initiation, % (n )**			73.2 (63)
	Overall
		N = 113	N = 151
ART initiation, % (n )**		96.4 (109)	78.1 (118)	<0.001

^*chi2 test.

^**in the 6 months following the date when treatment initiation criteria were met, among patients still on active follow-up.