Table 3. Comparative biodistribution of NODAGA-Z_HER2:S1, NOTA-Z_HER2:S1 and DOTA-Z_HER2:S1 labelled with gallium-68 and indium-111 after intravenous injection in female BALB/C nu/nu mice bearing SKOV-3 xenografts.

	DOTA-ZHER2:S1		NOTA-ZHER2:S1		NODAGA-ZHER2:S1
	68Ga	111In	68Ga	111In	68Ga	111In
Blood	0.7±0.1d	0.47±0.05a	0.3±0.0	0.64±0.08b	0.28±0.05f	0.5±0.1c
Lung	0.7±0.2d	1.0±0.3a	0.5±0.1	0.9±0.2	0.6±0.2	1.9±1.7
Liver	3.3±0.4	2.8±0.3a	3.7±0.3e	6.6±0.6b	2.4±0.6	3±1c
Spleen	1.5±0.3d	1.3±0.4	0.7±0.2	1.1±0.2	0.5±0.1f	1.1±0.3c
Kidney	295±31	305±32a	312±11	203±8b	294±22	291±32
Tumor	17.9±0.7d	20.9±0.7a	12.5±2.8	9±1b	16.1±0.7f	14.4±0.9c
Muscle	0.07±0.03	0.23±0.09a	0.09±0.03	0.06±0.03	0.15±0.03f	0.1±0.2c
Bone	0.09±0.05	0.8±0.1a	0.3±0.2	0.22±0.07	0.49±0.01f	0.2±0.6
GI tract*	0.7±0.1d	0.5±0.3	0.46±0.06	0.58±0.05b	0.7±0.2	0.9±0.2c
Carcass*	4.8±1.4	4±3	4.7±1.5	5±1	5.1±2.6	7±2c

Data are presented as an average % IA/g and standard deviation for four mice. Data concerning bone from one mice injected with ⁶⁸Ga-NOTA-Z_HER2:S1 and bone and muscle form one mice injected with ⁶⁸Ga-NODAGA-Z_HER2:S1were excluded due to low counts.

^asignificant difference (p<0.05) between ⁶⁸Ga-DOTA-Z_HER2:S1 and ¹¹¹In-DOTA-Z_HER2:S1.

^bsignificant difference (p<0.05) between ⁶⁸Ga-NOTA-Z_HER2:S1 and ¹¹¹In-NOTA-Z_HER2:S1.

^csignificant difference (p<0.05) between ⁶⁸Ga-NODAGA-Z_HER2:S1 and ¹¹¹In-NODAGA-Z_HER2:S1.

^dsignificant difference (p<0.05) between ⁶⁸Ga-DOTA-Z_HER2:S1 and ⁶⁸Ga-NOTA-Z_HER2:S1.

^esignificant difference (p<0.05) between ⁶⁸Ga-NOTA-Z_HER2:S1 and ⁶⁸Ga-NODAGA-Z_HER2:S1.

^fsignificant difference (p<0.05) between ⁶⁸Ga-NODAGA-Z_HER2:S1 and ⁶⁸Ga-DOTA-Z_HER2:S1.

^*Data for gastrointestinal (GI) tract and carcass are presented as %IA per whole organ.