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. 2013 Aug 1;8(8):e71326. doi: 10.1371/journal.pone.0071326

Figure 1. Ketamine and ARA 290 reduce mRNA for NDMA receptor subunits in established neuropathy.

Figure 1

Real time PCR data show that NMDA receptor subunits 1 (panel A), 2A (panel B), and 2B (panel C) are all modestly elevated one week following sciatic nerve injury. Administration of ketamine significantly reduces mRNA to baseline levels. In contrast, ARA 290 reduced mRNA for these receptor subunits to substantially below baseline (naïve). *p<0.05 versus vehicle, #p<0.05 between ketamine and ARA 290 treatments, **p<0.05 versus naïve.