| Adverse events |
Included adverse events: Extrapyramidal symptoms, Sedation, Dry mouth, Fatigue, Insomnia, Headache, Psychiatric disorders |
| Prolactin level normalization |
Hyperprolactinemia defined as prolactin level ≥60 µg/L, normal prolactin level was defined as a serum prolactin level of <30 ng/ml for the patients in Chinese study. Normal prolactin level was defined as a serum prolactin level of <24 ng/ml for women and <20 ng/ml for men in the study by shim. |
| Prolactin-related symptoms recovery |
Included prolactin-related symptoms: Oligomenorrhea, Amenorrhea, Galactorrhea |
| Discontinuation rate |
All reasons for study discontinuation were included in meta- analysis. |
| Improvement in psychiatric symptoms |
Measurements: In the change of the Positive and Negative Syndrome Scale total score of adjunctive aripiprazole compared with placebo in two studies; and the Brief Psychiatric Rating Scale score in three studies. |
