Table 4. Summary of the gene-gene interactions on total IgE production among newborns, infancy and early childhood.
| Interactions* | Best Model | Average testing Bal. Acc. (%) | Average CV consistency | P value§ | |
| Total CBIgE † | |||||
| 1 | IL13 (rs1295686) | 55.1 | 11/20 | 0.060 | |
| 2 | ADAM33 (rs597980) | CX3CL1 (rs4151117) | 51.9 | 6/20 | 0.252 |
| 3 | CCL17 (rs223900) | PTPN22 (rs1217395) | 55.5 | 13/20 | 0.006 |
| CX3CL10 (rs867562) | |||||
| 4 | CCL17 (rs223900) | IL5RA (rs163550) | 48.1 | 10/20 | 0.748 |
| CLECL1 (rs741199) | LY75 (rs1365801) | ||||
| Total IgE # , 1.5 years of age | |||||
| 1 | ADAM33 (rs528557) | 47.4 | 6/20 | 0.868 | |
| 2 | NPSR1 (rs324981) | FGF1 (rs2282797) | 62.4 | 19/20 | 0.006 |
| 3 | CD14 (rs2569190) | TXN (rs4135218) | 54.3 | 9/20 | 0.058 |
| MSRA (rs6984840) | |||||
| 4 | ADAM33 (rs528557) | CD14 (rs2569190) | 51.8 | 11/20 | 0.132 |
| TXN (rs4135218) | CLECL1 (rs2268146) | ||||
| Total IgE # , 3 years of age | |||||
| 1 | IL13 (rs1800925) | 57.4 | 18/20 | 0.021 | |
| 2 | IL13 (rs1800925) | CXCL12 (rs2297630) | 49.4 | 8/20 | 0.588 |
| 3 | IL13 (rs1800925) | CYFIP2 (rs767007) | 63.1 | 20/20 | <0.001 |
| PDE2A (rs755933) | |||||
| 4 | CD14 (rs2569190) | IFNGR2 (rs2268241) | 53.4 | 14/20 | 0.058 |
| GPIAP1 (rs7113413) | CAT (rs566979) | ||||
| Total IgE # , 6 years of age | |||||
| 1 | CD80 (rs2629396) | 47.3 | 10/20 | 0.132 | |
| 2 | PTPN22 (rs3765598) | IL5RA (rs163550) | 42.5 | 7/20 | 0.979 |
| 3 | CLEC2D (rs1560011) | CCL2 (rs2857656) | 67.2 | 19/20 | <0.001 |
| COLEC11 (rs10210631) | |||||
| 4 | NPSR1 (rs323922) | IL2RA (rs3118470) | 45.1 | 5/20 | 0.588 |
| CLEC2D (rs1560011) | CCL2 (rs2857656) | ||||
CV, Cross-validation; Bal. Acc., Balance accuracy.
*
Number of loci considered.
§
Significance of prediction error (empirical P value based on 10,000 permutations).
†
Cut off ≥0.5 (kU/L).
#
Higher (>75%) vs. lower tertile (<25%).