Table 1. Correlation between the clinicopathologic variables and Fibulin-3 expression in HCC.
Variable | Fibulin-3 protein | ||||
All cases | Low expression | High expression | ?2 | P valuea | |
Age (years)b | 1.177 | 0.278 | |||
<47.9 | 133 | 69 (51.9%) | 64 (48.1%) | ||
≥47.9 | 122 | 55 (45.1%) | 67 (54.9%) | ||
Gender | 0.024 | 0.878 | |||
Male | 227 | 110 (48.5%) | 117 (51.5%) | ||
Female | 28 | 14 (50%) | 14 (50%) | ||
HBsAg | 0.127 | 0.722 | |||
Positive | 222 | 105 (48.2%) | 115 (51.8%) | ||
Negative | 33 | 17 (51.5%) | 16 (48.5%) | ||
AFP (ng/ml) | 13.673 | <0.001 | |||
<20 | 106 | 37 (34.9%) | 69 (65.1%) | ||
≥20 | 149 | 87 (58.4%) | 62 (41.6%) | ||
Cirrhosis | 0.170 | 0.680 | |||
Yes | 184 | 88 (47.8%) | 96 (52.2%) | ||
No | 71 | 36 (50.7%) | 35 (49.3%) | ||
Tumor size (cm) | 0.913 | 0.339 | |||
<5 | 123 | 56 (45.5%) | 67 (54.5%) | ||
≥5 | 132 | 68 (51.5%) | 64 (48.5%) | ||
Tumor multiplicity | 0.619 | 0.431 | |||
Single | 136 | 63 (46.3%) | 73 (53.7%) | ||
Multiple | 119 | 61 (51.3%) | 58 (48.7%) | ||
Differentiation | 7.100 | 0.008 | |||
Well-Moderate | 157 | 66 (42.0%) | 91 (58.0%) | ||
Poor-Undifferentiated | 98 | 58 (59.2%) | 40 (40.8%) | ||
Stage | 5.978 | 0.014 | |||
I–II | 127 | 52 (40.9%) | 75 (59.1%) | ||
III–IV | 128 | 72 (56.3%) | 56 (43.7%) | ||
Vascular invasion | 0.484 | 0.487 | |||
Yes | 75 | 39 (52.0%) | 36 (48.0%) | ||
No | 180 | 85 (47.2%) | 95 (52.8%) | ||
Relapse | 0.764 | 0.382 | |||
Yes | 104 | 54 (51.9%) | 50 (48.1%) | ||
No | 151 | 70 (46.4%) | 81 (53.6%) |
Chi-squared test;
Mean age; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen.