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. 2013 Aug 1;8(8):e70511. doi: 10.1371/journal.pone.0070511

Table 1. Correlation between the clinicopathologic variables and Fibulin-3 expression in HCC.

Variable Fibulin-3 protein
All cases Low expression High expression ?2 P valuea
Age (years)b 1.177 0.278
<47.9 133 69 (51.9%) 64 (48.1%)
≥47.9 122 55 (45.1%) 67 (54.9%)
Gender 0.024 0.878
Male 227 110 (48.5%) 117 (51.5%)
Female 28 14 (50%) 14 (50%)
HBsAg 0.127 0.722
Positive 222 105 (48.2%) 115 (51.8%)
Negative 33 17 (51.5%) 16 (48.5%)
AFP (ng/ml) 13.673 <0.001
<20 106 37 (34.9%) 69 (65.1%)
≥20 149 87 (58.4%) 62 (41.6%)
Cirrhosis 0.170 0.680
Yes 184 88 (47.8%) 96 (52.2%)
No 71 36 (50.7%) 35 (49.3%)
Tumor size (cm) 0.913 0.339
<5 123 56 (45.5%) 67 (54.5%)
≥5 132 68 (51.5%) 64 (48.5%)
Tumor multiplicity 0.619 0.431
Single 136 63 (46.3%) 73 (53.7%)
Multiple 119 61 (51.3%) 58 (48.7%)
Differentiation 7.100 0.008
Well-Moderate 157 66 (42.0%) 91 (58.0%)
Poor-Undifferentiated 98 58 (59.2%) 40 (40.8%)
Stage 5.978 0.014
I–II 127 52 (40.9%) 75 (59.1%)
III–IV 128 72 (56.3%) 56 (43.7%)
Vascular invasion 0.484 0.487
Yes 75 39 (52.0%) 36 (48.0%)
No 180 85 (47.2%) 95 (52.8%)
Relapse 0.764 0.382
Yes 104 54 (51.9%) 50 (48.1%)
No 151 70 (46.4%) 81 (53.6%)
a

Chi-squared test;

b

Mean age; AFP, alpha-fetoprotein; HBsAg, hepatitis B surface antigen.