Table 2. Univariate and multivariate analyses of prognostic factors of overall survival.

Variable	All cases	Univariate			Multivariate
		Mean	Median	P value	HR (95% CI)	P value
Age (years)a				0.804
<47.9	133	50.2	39.0
≥47.9	122	48.6	38.0
Gender				0.408
Male	227	49.2	38.0
Female	28	52.5	NR
HBsAg				0.644
Positive	222	50.2	40.0
Negative	33	44.8	38.0
Cirrhosis				0.477
Yes	184	48.7	38.0
No	71	52.3	NR
AFP (ng/ml)				<0.001	1.753 (1.122-2.739)	0.014
<20	106	65.3	NR
≥20	149	38.9	27.0
Tumor size (cm)				<0.001	1.121 (0.752-1.671)	0.575
<5	123	59.6	NR
≥5	132	41.6	27.0
Tumor multiplicity				<0.001	1.074 (0.668-1.727)	0.767
Single	136	63.1	NR
Multiple	119	35.6	24.0
Differentiation				<0.001	1.059 (0.723-1.549)	0.770
Well-Moderate	157	57.1	NR
Poor-Undifferentiated	98	36.9	25.0
Stage				<0.001	5.199 (2.837-9.527)	<0.001
I–II	127	73.8	NR
III–IV	128	26.7	18.0
Vascular invasion				<0.001	1.197 (0.785-1.826)	0.402
Yes	75	28.4	18.0
No	180	58.6	NR
Relapse				<0.001	2.250 (1.464-3.457)	<0.001
Yes	104	30.9	24.0
No	151	65.1	NR
Fibulin-3				<0.001	0.468 (0.315-0.695)	<0.001
Low expression	131	34.1	26.0
High expression	124	62.0	NR

^aMean age; NR, not reached; HbsAg, hepatitis B surface antigen; AFP, alpha-fetoprotein; HR, hazard ratio; CI, confident interval.