Table 3. Univariate and multivariate analyses of prognostic factors of recurrence-free survival.

Variable	All cases	Univariate			Multivariate
		Mean	Median	P value	HR (95% CI)	P value
Age (years)a				0.725
<47.9	133	43.2	30.0
≥47.9	122	42.9	36.0
Gender				0.459
Male	227	44.7	35.0
Female	28	33.2	42.0
HBsAg				0.291
Positive	222	43.0	35.0
Negative	33	47.9	42.0
Cirrhosis				0.379
Yes	184	41.6	30.0
No	71	48.5	42.0
AFP (ng/ml)				<0.001	1.444 (0.974-2.142)	0.067
<20	106	53.0	57.0
≥20	149	36.0	26.0
Tumor size (cm)				<0.001	1.276 (0.857-1.899)	0.230
<5	123	53.2	NR
≥5	132	35.7	22.0
Tumor multiplicity				0.007	1.122 (0.748-1.682)	0.579
Single	136	49.3	42.0
Multiple	119	36.7	26.0
Differentiation				0.001	1.202 (0.819-1.763)	0.348
Well-Moderate	157	49.6	53.0
Poor-Undifferentiated	98	32.1	26.0
Stage				<0.001	2.262 (1.319-3.879)	0.003
	127	61.5	NR
III–IV	128	24.5	18.0
Vascular invasion				<0.001	2.665 (1.718-4.133)	<0.001
Yes	75	19.6	15.0
No	180	57.2	NR
Fibulin-3				0.005	0.676 (0.466-0.979)	0.038
Low expression	131	34.3	27.0
High expression	124	49.5	53.0

^aMean age; NR, not reached; HbsAg, hepatitis B surface antigen; AFP, alpha-fetoprotein; HR, hazard ratio; CI, confident interval.