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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Am Coll Nutr. 2009 Dec;28(6):678–686. doi: 10.1080/07315724.2009.10719801

Table 4.

Changes in plasma vitamin D metabolites over six months, by treatment group (mean ± SEM)

Baseline Follow-up Change1 P1 Change22 P2 Change33 P3
Placebo (n=21)
25(OH)D (nmol/L) 51.1 (3.9) 44.7 (3.8) −6.3 (5.6) 0.30 −4.9 (3.1) 0.10 −4.6 (3.2) 0.10
1,25(OH)2D (pmol/L) 94.0 (6.1) 89.1 (5.6) −4.9 (8.3) 0.60 −5.3 (15.5)7 0.70 0.5 (16.7)7 0.97
Baseline Follow-up Change1 P1 Change22 P2 Change33 P3
Calcium4,5(n=21)
25(OH)D (nmol/L) 64.1 (4.0) 58.0 (4.8) −6.2 (6.2) 0.30 −0.7 (4.4) 0.90 0.8 (4.2) 0.90
1,25(OH)2D (pmol/L) 108.9 (17.8) 76.0 (6.5) −32.9 (19.5) 0.09 −27.8 (22.0)7 0.20 −23.9 (22.5)7 0.30
Baseline Follow-up Change1 P1 Change22 P2 Change33 P3
Vitamin D4,6 (n=22)
25(OH)D (nmol/L) 52.6 (4.4) 73.7 (3.8) 21.1 (5.9) 0.001 26.0 (4.4) 0.001 28.9 (4.3) 0.001
1,25(OH)2D (pmol/L) 106.7 (11.6) 113.8 (14.3) 7.0 (18.4) 0.70 12.3 (21.7)7 0.60 13.3 (22.6) 0.60
Baseline Follow-up Change1 P1 Change22 P2 Change33 P3
Calcium+Vitamin D5,6 (n=21)
25(OH)D (nmol/L) 52.3 (5.0) 71.3 (4.3) 19.0 (6.7) 0.007 25.4 (4.4) 0.001 25.7 (4.2) 0.001
1,25(OH)2D (pmol/L) 90.9 (6.31) 88.1 (15.1) −2.8 (15.8) 0.90 0.9 (22.0)7 0.97 2.9 (22.3)7 0.90
1

Difference between follow-up and baseline in each treatment group (without any adjustment); corresponding p-value adjusted for multiple comparisons (Tukey-Kramer)

2

Difference in treated groups adjusted for placebo effect, i.e. difference between follow-up and baseline in treated group compared with the corresponding difference in placebo group (time*RX interaction term in model); corresponding p-value adjusted for multiple comparisons (Tukey-Kramer)

3

Difference in treated group (as in Change2) additionally adjusted for season of blood draw; corresponding p-value adjusted for multiple comparison (Tukey-Kramer)

4

Difference (Change2,3) in pre-post intervention 25(OH)D in calcium only vs vitamin D only group p<0.008; Bonferroni correction for multiple comparisons

5

Difference (Change2,3) in pre-post intervention 25(OH)D in calcium only vs. calcium plus vitamin D group p<0.008; Bonferroni correction for multiple comparisons

6

Difference (Change2,3) in pre-post intervention 25(OH)D in vitamin D only vs. calcium plus vitamin D group not significant; Bonferroni correction for multiple comparisons

7

Difference (Change2,3) in pre-post intervention 1,25(OH)2D not significant; Bonferroni correction for multiple comparisons.