Table 2.

Adjusted Changes in WOMAC Scores and Radiograph Scores According to Global Assessment of Change Categories^*

	Change in WOMAC Total† Mean (SD)	Change in WOMAC Pain† Mean (SD)	Change in WOMAC Function† Mean (SD)	Change in Radiographic Severity Scores (JSN + Osteophytes) Mean (SD)	Change in JSN Mean (SD)	Change in Osteophytes Mean (SD)
Knee Global Assessment of Change
One or Two Knees Better (No Knee Worse)	−0.87 (23.0)	−0.10 (6.1)	0.70 (15.7)	0.76 (1.48)	0.53 (1.01)	0.35 (0.86)
Both Knees Same or Never Had Symptoms	−1.76 (15.6)	−0.40 (3.9)	−1.09 (10.5)	0.87 (1.54)	0.47 (0.64)	0.47 (0.91)
One Knee Worse	5.12 (17.6)	1.25 (4.6)	3.46 (11.6)	1.11 (1.56)	0.64 (1.05)	0.59 (0.96)
Both Knees Worse	8.20 (17.5)	1.35 (4.3)	5.92 (11.8)	1.31 (1.66)	0.75 (1.09)	0.70 (1.11)
p-value for linear trend	0.001	0.027	0.004	0.259	0.483	0.259
Hip Global Assessment of Change
One or Two Hips Better (No Hip Worse)	−11.3 (21.1)	−3.11 (4.2)	−6.00 (15.5)	0.19 (0.40)	0.13 (0.34)	0.06 (0.25)
Both Hips Same or Never Had Symptoms	0.27 (16.4)	−0.29 (4.3)	0.46 (10.9)	0.32 (0.88)	0.12 (0.51)	0.19 (0.61)
One Hip Worse	5.24 (17.2)	1.50 (4.1)	3.46 (11.8)	0.45 (0.99)	0.13 (0.43)	0.33 (0.79)
Both Hips Worse	7.17 (17.6)	1.52 (4.5)	4.88 (12.3)	0.36 (0.85)	0.14 (0.51)	0.22 (0.55)
p-value for linear trend	<0.001	<0.001	<0.001	0.304	0.922	0.191
Back Global Assessment of Change
Better	−4.13 (19.6)	−0.26 (5.1)	−3.00 (12.4)	1.05 (1.51)	0.68 (0.89)	0.37 (0.76)
Same or Never Had Symptoms	0.75 (16.5)	−0.02 (4.2)	0.65 (11.0)	1.27 (1.95)	0.74 (1.03)	0.52 (1.04)
Worse	4.54 (17.6)	0.85 (4.3)	3.32 (12.2)	1.54 (2.11)	0.94 (1.18)	0.61 (1.06)
p-value for linear trend	0.023	0.275	0.013	0.092	0.110	0.110

^*All analyses adjusted for age, gender, BMI, baseline radiographic severity, and time between baseline and follow-up assessments

^†Negative WOMAC change scores indicate improved symptoms and function; positive scores indicate worse symptoms and function.