Table 1.

Regression coefficients predicting dementia diagnosis or memory score in non-Hispanic ADAMS participants, based on most recent core interview direct and proxy neuropsychological assessments and demographic (n=745)

	Dementia			Memory Score
	Logistic Regression Coefficientse	SE	P	Linear Regression Coefficients	SE	P
Predictor variablea
Intercept	4.608	1.459	.002	.422	.155	.007
Proxy Respondent (1=yes; 0=no)	1.889	2.069	.361	−1.388	.179	<.001
Word Immediate Recall	.933	.388	.016	.116	.026	<.001
Word Immediate Recall Squared	−.266	.070	<.001	-	-	-
Word Delayed Recall	−.797	.159	<.001	.024	.025	.331
TICSb	−1.075	.324	.001	-	-	-
TICS Squared	.043	.020	.036	-	-	-
IQCODEc (centered at 5)	2.220	1.119	.047	−.068	.070	.332
Proxy Memory Scored(centered at 5)	1.096	.423	.010	−.210	.083	.011
Male	−.854	.507	.092	−.132	.061	.031
Age (centered at 70)	.095	.025	<.001	−.067	.008	<.001
Black	−.695	.445	.118	−.398	.086	<.001
Word Delayed Recall*male	.543	.208	.009	-	-	-
Word Delayed Recall*age	-	-	-	.010	.002	<.001
IQCODE*male	1.551	.543	.004	−.446	.080	<.001
Proxy Respondent*Age	-	-	-	.039	.011	<.001

^aAll predictor variables were drawn from the most recently available HRS core interview. Quadratic and interaction terms that were not statistically significant predictors of one of the outcomes were dropped from the model for that outcome.

^bStandard TICS scoring includes immediate word recall, but we treated the immediate word recall as a separate item. We omitted items for “naming scissors” (because of low correlation with other items) and the second attempt at counting backwards from 20 (because of apparent inconsistencies in administration). TICS scores therefore ranged from 0 to 13.

^cProxies completed a 16-item version of the Jorm Informant Questionnaire for Cognitive Decline (IQCode). The IQCode assesses decline in several cognitively demanding tasks, such as recognizing familiar faces or understanding movie plots. For each task, proxies rank the participant on a 5-point scale (centered in this analysis to range from −4: much better to 0: much worse).

^dProxies rated the subject’s memory performance on a 5 point Likert scale (centered in this analysis to range from −4: excellent to 0: poor).

^eThese regression coefficients can be directly applied to estimate odds of dementia, based on individual age, sex, race, and either proxy assessments or performance on the direct neuropsychological assessments. Estimates are from a cohort and odds can be directly converted to probabilities.