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GC (open circles), but not CG (closed squares) or C (open squares), enhances DNA cleavage mediated by human topoisomerase IIα (hTIIα; left) and IIβ(hTIIβ; right). Data for GCG (closed circles) are shown for comparison. Levels of DNA cleavage were quantified from the band of linear DNA and expressed relative to reactions carried out in the absence of catechin. Error bars represent standard deviations for three independent experiments.
