Figure 10.

Blocking of uncoupling protein 2 (UCP2) with genipin attenuates obstructive nephropathy in mice. (a–h) Representative hematoxylin and eosin staining (a d) or Masson–Trichrome staining (e–h) micrographs show kidney histology in sham control treated with vehicle (a. e) or genipin (b, f), and unilateral ureteral occlusion (UUO) mice treated with vehicle (c, g) or genipin (d, h). (i): Morphometric analysis of kidney fibrosis in the UUO model (*P<0.05 compared with sham control; n=5; ^#P<0.05 vs UUO mice treated with vehicle; mean±s.e.m. as shown). (j) Western blot results show FN and α-SMA abundance in kidney from mice administrated with genipin or vehicle. (k) Graphic presentation of the relative abundance of FN and α-SMA protein in kidneys (*P<0.05 compared with sham; n=5; ^#P<0.05 vs UUO mice; n=5; mean±s.e.m. as shown).