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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neurochem Res. 2012 Apr 10;37(11):2339–2350. doi: 10.1007/s11064-012-0766-5

Fig. 3.

Fig. 3

Chronic infusion of MSO into the hippocampal formation of rats causes inhibition of GS, and in some cases neuropathological changes that resemble hippocampal sclerosis as reported earlier [17, 80]. a–d: a silver staining technique for labeling degenerating neurons and fiber tracts reveals numerous stained (injured) neurons and fibers preferentially in area CA1 in a rat infused with MSO into the hippocampal formation (b, d) whereas a rat infused with 0.9 % NaCl does not reveal stained (injured) tissue elements (a, c). Magnification: A = B; C = D. Abbreviations: CA1-3 hippocampal subfields Cornu Ammonis 1-3, MSO methionine sulfoximine. (Adapted from [17] and reproduced with permission from Brain/Oxford University Press)