Diffusion coefficients were determined by FRAP data fitting (DFitting, Eq. 3), by the DConfocal equation (Eq. 5), by the Soumpasis equation using rn (Drn), and by the Soumpasis equation using re (Dre) for individual confocal FRAP curves (N≥6). Dashed box indicates the range of EGFP’s diffusion coefficients in the cytosol reported in the literature. re was measured from an averaged postbleach profile (n=1,N=10 cells) and D’s were obtained from individual FRAP data (n=1, N=8,10,10, and 8 cells). *, p<0.05 compared to DFitting, Student’s t-test.