Skip to main content
. 2013 Aug 2;3:2344. doi: 10.1038/srep02344

Figure 5. Working models for the role of Lys63-linked polyubiquitination in BRAF activation.

Figure 5

(A) Normal BRAF activation. Upon EGF binding to its receptor, the Ras-GTP recruits BRAF and induces its phosphorylation at Thr 599-Ser 602 residues and Lys63-linked polyubiquitination at Lys 578 within its kinase domain, which in turn mediates the activation of MEK-ERK and regulates downstream gene expression. (B) Oncogenic BRAF activation. BRAF with constitutively active mutation gains its Lys63-linked polyubiquitination at Lys 578 to activate downstream effector gene independent of RAS activity.