Table 1. Demographic data and psychometric assessment of the patients.
| a | ||||||
|---|---|---|---|---|---|---|
|
Mean±s.d.
(min–max) |
P-value |
|||||
| CTRL (n=21) | MCI (n=23) | AD (n=23) | CTRL vs MCI | CTRL vs AD | MCI vs AD | |
| CDR-GS 0 | n=21 | n=1 | ||||
| CDR-GS 0.5 | n=22 | n=7 | ||||
| CDR-GS 1 | n=10 | |||||
| CDR-GS 2 | n=6 | |||||
| MMSE | 29.71±0.46 | 24.78±2.13 | 17.57±2.86 | <0.0001 | <0.0001 | <0.0001 |
| (29–30) | (21–28) | (13–24) | ||||
| ADAS-cog | 0 | 18.04±8.04 | 36.91±11.02 | <0.0001 | <0.0001 | <0.0001 |
| (2–36) | (22–59) | |||||
| CDR-SB | 0 | 2.3±1.35 | 6.5±3.81 | <0.0001 | <0.0001 | <0.0001 |
| (0–5.5) | (2–14) | |||||
| Mean age, year | 65.48±5.31 | 69.57±9.52 | 77.39±6.83 | 0.084 | <0.0001 | 0.0027 |
| (60–77) | (50–82) | (66–90) | ||||
| Sex, female/male | 10/11 | 10/13 | 15/8 | 0.55 | 0.37 | 0.56 |
| (%) | (47.62/52.38) | (43.48/56.52) | (65.22/34.78) | |||
| b | ||||||
|---|---|---|---|---|---|---|
|
Mean±s.d.
(min–max) |
P-value |
|||||
| CTRL (n=21) | MCI ⩽1.5 (n=9) | MCI ⩾2 (n=14) | CTRL vs MCI ⩽1.5 | CTRL vs MCI ⩾2 | MCI ⩽1.5 vs MCI ⩾2 | |
| MMSE | 29.71±0.46 (29–30) | 25.89±1.83 (23–28) | 24.07±2.06 (21–28) | <0.0001 | <0.0001 | 0.043 |
| ADAS-cog | 0 | 16±7.67 (2–27) | 19.36±8.27 (7–36) | <0.0001 | <0.0001 | 0.34 |
| CDR-SB | 0 | 1±0.5 (0–1.5) | 3.14±1 (2–5.5) | <0.0001 | <0.0001 | <0.0001 |
| Age, year | 65.48±5.31 (60–77) | 70.44±7.94 (58–81) | 69±10.67 (50–82) | 0.053 | 0.20 | 0.73 |
| Sex, female/male | 10/11 | 4/5 | 6/8 | 0.88 | 0.79 | 0.94 |
| (%) | (47.62/52.38) | (44.4/55.6) | (42.8/57.2) |
Abbreviations: AD, Alzheimer's disease; ADAS-cog, Alzheimer's Disease Assessment Scale–Cognitive Subscale; CDR-GS, Cognitive Dementia Rating–Global Score; CDR-SB, Cognitive Dementia Rating–Sum of Boxes; CTRL, controls; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination.