Table 2b. Diagnostic potential (mROC) of the different CSF biomarkers as univariate variables for MCI diagnosis.
| CTRL vs MCI | Aβ1-42 | T-Tau | P-Tau | Aβ11-40 | Aβ11-42 | Aβ17-40 | Aβ17-42 |
|---|---|---|---|---|---|---|---|
| Median (pg ml−1) | 535.14 | 56.6 | 27.47 | 147.58 | 22.21 | 37.85 | 11.15 |
| Cutoff (pg ml−1) | −490.47 | 64.16 | 27.26 | −146.66 | −21.87 | 46.15 | −11.05 |
| Sensitivity (%) | 60.87 | 60.87 | 69.57 | 69.57 | 65.22 | 52.17 | 60.87 |
| Specificity (%) | 76.19 | 76.19 | 66.67 | 71.43 | 76.19 | 66.67 | 61.9 |
| NPV (%) | 64.00 | 64.00 | 66.67 | 68.18 | 66.67 | 56.00 | 59.09 |
| PPV (%) | 73.68 | 73.68 | 69.57 | 72.73 | 75.00 | 63.16 | 63.64 |
| AUC | 0.704 | 0.706 | 0.684 | 0.739 | 0.708 | 0.537 | 0.594 |
| 95% Confidence interval | (0.547–0.861) | (0.548–0.864) | (0.522–0.847) | (0.588–0.890) | (0.548–0.868) | (0.360–0.715) | (0.419–0.769) |
| P-value (Delong's test) | 0.021 | 0.019 | 0.036 | 0.006 | 0.018 | 0.672 | 0.285 |
Abbreviations: AUC, area under the curve; CSF, cerebrospinal fluid; CTRL, controls; MCI, mild cognitive impairment; NPV, negative predictive value; PPV, positive predictive value; P-Tau, phosphorylated Tau; T-Tau, total Tau.
The cut-offs were chosen to yield the highest Youden's index. P-values (DeLong's test) represent the comparison of biomarkers with AUC=0.5.