Table 3. Diagnostic potential (mROC) of the different CSF biomarkers as multivariate variables for MCI diagnosis.

CTRL vs MCI	T-Tau+P-Tau+Aβ1-42 (Z1)	T-Tau+Aβ11-40+Aβ17-40 (Z2)
Cutoff	−0.79	−1.28
Sensitivity (%)	60.87	73.91
Specificity (%)	66.67	95.24
NPV (%)	60.87	76.92
PPV (%)	66.67	94.44
AUC	0.727	0.89
95% Confidence interval	(0.575–0.878)	(0.791–0.990)
P-value (Delong's test)	0.01	<0.0001

Abbreviations: AUC, area under the curve; CSF, cerebrospinal fluid; CTRL, controls; MCI, mild cognitive impairment; NPV, negative predictive value; PPV, positive predictive value; P-Tau, phosphorylated Tau; T-Tau, total Tau.

The cutoffs were chosen to yield the highest Youden's index. P-values (DeLong's test) represent the comparison of biomarkers with AUC=0.5.