Table 1. Characteristics of the discovery and replication samples.
|
Discovery sample |
Replication sample |
|
|---|---|---|
| Characteristics | (n=124) | (n=665) |
| Female % | 74 | 56 |
| Age (range) | 44.5 (21–63) | 20.5 (18–40) |
| Depression scorea | 3.6 (0–9) | 5.4 (0–34) |
| Caucasian % | 100 | 100 |
| MTHFR C677T genotype (rs1801133) | ||
| T/T, % | 12 | 10 |
| T/C, % | 40 | 43 |
| C/C, % | 48 | 47 |
| HWE (P-value) | 0.32 | 0.94 |
| Childhood traumab | 44 | 1.4 (1.0–4.3) |
Abbreviations: HWE, Hardy–Weinberg equilibrium; MTHFR, methylenetetrahydrofolate reductase.
a
Discovery sample: Hamilton depression rating scale (HDRS) total score; replication sample: Beck Depression Inventory (BDI) total score.
b
Discovery sample: percent experienced traumatic childhood event(s) (TCE); replication sample: total score Childhood Trauma Questionnaire (CTQ).