Table 3. Effect of MTHFR modified by TCE in the discovery sample.
| β | s.e.β | Wald | d.f. | P-value | RR | |
|---|---|---|---|---|---|---|
| MTHFR | −0.081 | 0.284 | 0.080 | 1 | 0.777 | 0.923 |
| TCE | 0.368 | 0.296 | 1.544 | 1 | 0.214 | 1.445 |
| MTHFR × TCE a | 0.979 | 0.410 | 5.713 | 1 | 0.017 | 2.663 |
Abbreviations: MTHFR, methylenetetrahydrofolate reductase; TCE, traumatic childhood event; RR, relative risk.
Cox regression analysis.
MTHFR: T-allele carrying patients versus non-T-allele carrying patients, with non-T-allele carriers as the reference category.
TCE: experienced TCE yes/no, with no TCE as the reference category.
a
P=0.016 after adjustment for age, gender and antidepressant (AD) use.