Table 1.

Single-SNP Disease Model

Disease Model	f 0 a	f 1	f 2
Additive	prev /(1– 2 p + 2 pλ) b	λ f0	(2 λ-1)f0
Dominant	prev /((1 – p) 2 + λp(2-p))	λ f0	λ f0
Recessive	prev /(1 + p 2 λ2 – p 2)	f0	λ f0

^aThe f₀, f₁, f₂ are three penetrances of genotypes.

^bIn additive and dominant models, λ = λ₁, and in a recessive model, λ = λ₂.