Table 4.
The Estimated Power of Gene-based Association Tests, Assuming One Disease-related SNP Occurs Within the Gene, Under Different Sample Sizes and Different Disease Models
| Disease Model | GRRa | N=400 | N=800 | |||||
|---|---|---|---|---|---|---|---|---|
| maxTb | Entropyc | SNPd | maxT | Entropy | SNP | |||
| Additive | 1.4 | 1 | 0.56 | 0.60 | 0.95 | 0.92 | 0.94 | |
| 1.6 | 1 | 0.91 | 0.955 | 1 | 1 | 1 | ||
| 1.8 | 1 | 0.975 | 0.990 | 1 | 1 | 1 | ||
| Dominant | 1.4 | 0.47 | 0.39 | 0.36 | 0.65 | 0.62 | 0.74 | |
| 1.6 | 0.75 | 0.65 | 0.73 | 0.94 | 0.90 | 0.95 | ||
| 1.8 | 0.88 | 0.89 | 0.90 | 0.99 | 0.99 | 0.99 | ||
| Recessive | 1.4 | 0.22 | 0.26 | 0.20 | 0.29 | 0.29 | 0.37 | |
| 1.6 | 0.32 | 0.34 | 0.34 | 0.64 | 0.74 | 0.77 | ||
| 1.8 | 0.54 | 0.63 | 0.59 | 0.86 | 0.92 | 0.98 | ||
a
GRR, genotype relative risks.
b
Data were obtained using the maximum test statistic method.
c
Data were obtained using the entropy-based method.
d
Data were obtained using the single-SNP–based method.