Table 5.

The Estimated Power of Gene-based Association Tests, Assuming that Two Disease-related SNPs Occur Within a Gene, Under Different Sample Sizes and Different Disease Models

Disease Model	(BL,GE) a	N=400			N=800
		maxTb	Entropyc	SNPd	maxT	Entropy	SNP
Model 1	(1,0.5)	0.31	0.42	0.19	0.61	0.76	0.37
	(1,0.7)	0.54	0.71	0.35	0.87	0.93	0.72
	(1,0.9)	0.78	0.89	0.61	0.99	1	0.96
Model 2	(1,0.5)	0.20	0.29	0.19	0.52	0.54	0.49
	(1,0.7)	0.34	0.45	0.38	0.66	0.77	0.79
	(1,0.9)	0.52	0.65	0.59	0.90	0.96	0.97
Model 3	(1,0.5)	0.17	0.25	0.10	0.51	0.49	0.54
	(1,0.7)	0.43	0.56	0.43	0.66	0.77	0.76
	(1,0.9)	0.41	0.59	0.50	0.84	0.91	0.92

^aBL, the baseline effect; GE, is the genotypic effect.

^bData were obtained using the maximum test statistic method.

^cData were obtained using the entropy-based method.

^dData were obtained using the single-SNP–based method.