Table 6.

The Estimated Power of Gene-based Association Tests, Assuming Three Disease-related SNPs Occur Within a Gene, Under Different Sample Sizes and Different Disease Models

Disease Model	(BL,GE)a	N=400			N=800
		maxTb	Entropyc	SNPd	maxT	Entropy	SNP
Model 1	(1,0.5)	0.54	0.56	0.42	0.92	0.88	0.81
	(1,0.7)	0.87	0.77	0.63	1	1	1
	(1,0.9)	0.95	0.94	0.87	1	1	1
Model 2	(1,0.5)	0.56	0.50	0.33	0.94	0.91	0.81
	(1,0.7)	0.87	0.76	0.73	1	0.99	0.99
	(1,0.9)	0.96	0.96	0.91	1	1	1
Model 3	(1,0.5)	0.06	0.05	0	0.01	0.08	0.03
	(1,0.7)	0.08	0.13	0.05	0.06	0.16	0.02
	(1,0.9)	0.04	0.19	0.03	0.05	0.20	0.05

^aBL, the baseline effect; GE, is the genotypic effect.

^bData were obtained using the maximum test statistic method.

^cData were obtained using the entropy-based method.

^dData were obtained using the single-SNP–based method.