Table 1.
Structural and Functional Features of Some KRAB-ZNFs
| Metabolism | |||||||
|---|---|---|---|---|---|---|---|
| Protein | Species | Chromosomal Localization | KRAB | Zinc Fingers | Expression Profile | Functional Role | References |
| ZNF202 | Human | 11q.23.3 | KRAB+SCAN | 8 | ubiquitous | Lipids Metabolism | [56-58] |
| ZNF224 | Human | 19q13.2 | KRAB-A+b box | 19 | ubiquitous | Glycolysis Oxidative metabolism | [62, 63, 65] |
| ZNF236 | Human | 18q22.3-23 | KRAB-A box | 25/30 | ubiquitous | Glucose metabolism | [64] |
| Rsl1 | Mouse | 13B3 | KRAB-A+B box | 3 | liver | Lipids homeostasis Sexual dimorphism | [66, 67] |
| Rsl2 (Zfp429) | Mouse | 13B3 | KRAB-A+B box | 3 | liver | Lipids homeostasis | [66, 67] |
| Development and Differentiation | |||||||
| Protein | Species | Chromosomal Localization | KRAB | Zinc Fingers | Expression Profile | Functional Role | References |
| ZNF268 | Human | 12q24.33 | KRAB-A+B box | 14 | erythrocytes | haematopoiesis | [68, 69] |
| ZNF300 | Human | 5q33.1 | KRAB-A+b box | 12 | promyelocytes | haematopoiesis | [70, 71] |
| ZNF304 | Human | 19q13.4 | KRAB-A box | 13 | lymphocytes | lymphocyte activation | [72] |
| ZNF230 | Human | 19q13.31 | KRAB-A box | 4 | testis | spermatogenesis | [73] |
| ZNF463 | Human | 19q13.42 | KRAB-A+B box | 12 | testis | spermatogenesis | [74] |
| AJ18 | Rat | 11B1.3 | KRAB-A box | 11 | bone | osteogenesis | [75] |
| NT2 | Mouse | 16A1 | KRAB-A box | 9 | cartilage | development | [76] |
| ZNF359 | Human | 16q22 | KRAB-A+B box | 16 | heart | cardiogenesis | [77] |
| ZFP28 | Human | 19q13.41 | KRAB-A box | 14 | heart | cardiogenesis | [77] |
| ZFP57 | Human | 6p22.1 | KRAB-A box | 6 | ovary, testis | imprinting | [40, 41] |
| Zfp157 | Mouse | 5G2 | KRAB-A+B box | 11 | mammary gland | alveologenesis | [78] |
| Apoptosis and Cancer | |||||||
| Protein | Species | Chromosomal Localization | KRAB | Zinc Fingers | Expression Profile | Functional Role | References |
| ZNF224 | Human | 19q13.2 | KRAB-A+b box | 19 | ubiquitous | Control of apoptosis | [53, 79, 80] |
| ZNF382 | Human | 19q13.12 | KRAB-A+B box | 6 | heart | Tumor suppressor gene | [81] |
| ZNF545 | Human | 19q13.12 | KRAB-A box | 8 | ubiquitous | Tumor suppressor gene | [82] |
| ZBRK1 | Human | 19q13.41 | KRAB-A box | 8 | skeletal muscle | Tumor suppressor gene | [83-86] |
| Apak | Human | 19q13.12 | KRAB-A+b box | 19 | ubiquitous | Regulator of apoptosis | [88, 89] |
| ZNF307 | Human | 6p21 | KRAB+SCAN | 7 | ubiquitous | p53 degradation, apoptosis | [90] |
| Degenerative neurological diseases | |||||||
| Protein | Species | Chromosomal Localization | KRAB | Zinc Fingers | Expression Profile | Functional Role | References |
| ZNF746 | Human | 7q36.1 | KRAB-A box | 4 | ubiquitous | Parkinson’s disease | [91] |
| ZNF224 | Human | 19q13.2 | KRAB-A+b box | 19 | ubiquitous | Alzheimer’s disease | [92] |