Table 4.

Age-stratified meta-analyses combining multivariable results for incident hypertension from the Nurses’ Health Study II, Nurses’ Health Study I 1986 baseline, and Nurses’ Health Study I 2000 baseline

	Aged <50 years	Aged 50–59 years	Aged 60–69 years	Aged >70 years
No. of participants	76,737	51,534	26,366	9,808
Sleep duration in hours	Incident hypertension	Incident hypertension	Incident hypertension	Incident hypertension
≤5 hours
No. of cases	577	531	257	162
HR (95% CI)	1.20 (1.09–1.31)	1.11 (1.00–1.23)	1.00 (0.88–1.15)	1.05 (0.89–1.25)
6 hours
No. of cases	2,406	2,264	1,303	657
HR (95% CI)	1.10 (0.99–1.22)	1.04 (0.99–1.10)	1.05 (0.97–1.12)	0.99 (0.90–1.09)
7 hours
No. of cases	3,713	3,447	2,235	1,125
HR (95% CI)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
8 hours
No. of cases	2,013	1,849	1,495	798
HR (95% CI)	1.02 (0.94–1.10)	1.01 (0.95–1.07)	0.99 (0.91–1.09)	0.90 (0.82–0.99)
≥9 hours
No. of cases	459	401	368	213
HR (95% CI)	1.00 (0.91–1.11)	1.00 (0.86–1.16)	0.98 (0.87–1.09)	0.89 (0.77–1.04)

Controlling for age, diabetes, hypercholesterolemia, body mass index, race, Hispanic ethnicity, menopause, smoking, physical activity, alcohol, caffeine, Dietary Approaches to Stop Hypertension diet, aspirin, acetaminophen, nonaspirin Non-Steroidal Anti-Inflammatory Drugs, family history of hypertension, snoring, and shift work.

Abbreviations: CI, confidence interval; HR, hazard ratio.