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Sirolimus predicted hepatic and intestinal bioavailabilities. Hepatic (Fh, a) and intestinal (Fg, b) availabilities of sirolimus were predicted based on the well-stirred model and the Qgut model, respectively, using total CYP3A content data of von Richter et al. (2004), in which genotypes of CYP3A5*1/*3 (open circle) and *3/*3 (closed circle) were investigated.17
