Table 2.

Polymorphisms related to endothelial function and vascular remodeling and association with AVF failure

Gene	Name	SNP	Genotype	n	HR (95% CI)	P
MMP1	Matrix metallopeptidase 1	rs11292517	−/−	132	1 (reference)
			−/C	213	0.92 (0.67 to 1.28)	0.64
			CC	103	0.86 (0.58 to 1.28)	0.47
NOS3	Nitric oxide synthesis 3	rs1799983	GG	224	1 (reference)
			GA	188	1.26 (0.94 to 1.69)	0.12
			AA	44	0.88 (0.52 to 1.50)	0.64
ELN	Elastin	rs2071307	GG	185	1 (reference)
			GA	207	1.30 (0.96 to 1.75)	0.09
			AA	62	1.01 (0.64 to 1.60)	0.97
ANXA5	Annexin A5	rs4833229	CC	146	1 (reference)
			TC	218	0.85 (0.62 to 1.16)	0.30
			TT	91	0.85 (0.57 to 1.26)	0.42
ANXA5	Annexin A5	rs6830321	GG	132	1 (reference)
			GA	216	0.79 (0.57 to 1.09)	0.15
			AA	106	0.88 (0.61 to 1.29)	0.52
LRP1	LDL receptor-related protein 1	rs1466535	GG	192	1 (reference)
			GA	207	1.31 (0.97 to 1.78)	0.08
			AA	56	1.75 (1.15 to 2.66)	0.01
QKI	Quaking	rs3857504	CC	308	1 (reference)
			TC	126	1.16 (0.85 to 1.58)	0.35
			TT	12	1.67 (0.78 to 3.57)	0.19
QKI	Quaking	rs3763197	TT	323	1 (reference)
			TC	122	1.10 (0.81 to 1.50)	0.54
			CC	9	1.10 (0.41 to 2.96)	0.86
QKI	Quaking	rs2759393	CC	268	1 (reference)
			CA	157	0.96 (0.72 to 1.30)	0.80
			AA	24	0.56 (0.26 to 1.20)	0.13
—	12q23.2	rs10861032	TT	316	1 (reference)
			TC	122	0.99 (0.72 to 1.37)	0.97
			CC	17	1.48 (0.76 to 2.92)	0.25
—	12q23.2	rs9804922	CC	385	1 (reference)
			TC	68	0.81 (0.53 to 1.24)	0.33
			TT	2	1.32 (0.18 to 9.40)	0.78

AVF, arteriovenous fistula; SNP, single nucleotide polymorphism; HR, hazard ratio; CI confidence interval.