Table 3.

Polymorphisms in growth factor related genes and association with AVF failure

Gene	Name	SNP	Genotype	n	HR (95% CI)	P
CDKN1B	Cyclin-dependent kinase inhibitor 1B	rs36228499	CC	147	1 (reference)
(p27kip1)			CA	234	1.01 (0.74 to 1.39)	0.93
			AA	73	1.16 (0.76 to 1.76)	0.49
CTGF	Connective tissue growth factor	rs6918698	CC	128	1 (reference)
			GC	216	0.87 (0.63 to 1.20)	0.40
			GG	108	0.87 (0.59 to 1.28)	0.48
FGFR4	Fibroblast growth factor receptor 4	rs351855	GG	210	1 (reference)
			GA	170	1.10 (0.82 to 1.49)	0.53
			AA	52	0.69 (0.41 to 1.16)	0.16
KLF5	Kruppel-like factor 5	rs3812852	AA	393	1 (reference)
			GA	62	0.97 (0.65 to 1.44)	0.86
			GG	1	1.95 (0.27 to 13.95)	0.51
PDGFD	Platelet-derived growth factor D	rs974819	CC	225	1 (reference)
			TC	183	0.93 (0.69 to 1.25)	0.62
			TT	46	1.18 (0.75 to 1.86)	0.48
PDGFD	Platelet-derived growth factor D	rs496339	AA	366	1 (reference)
			GA	84	0.99 (0.69 to 1.42)	0.95
			GG	4	0.49 (0.07 to 3.51)	0.48
TGFBR1	TGF-β receptor 1	rs1626340	AA	282	1 (reference)
			GA	136	1.06 (0.77 to 1.44)	0.74
			AA	19	1.01 (0.50 to 2.07)	0.97
TGFBR2	TGF-β receptor 2	rs1036095	GG	266	1 (reference)
			GC	165	0.86 (0.64 to 1.17)	0.34
			CC	24	0.64 (0.32 to 1.32)	0.23
TGFBR2	TGF-β receptor2	rs4522809	AA	126	1 (reference)
			GA	237	1.34 (0.94 to 1.89)	0.10
			GG	90	1.42 (0.93 to 2.16)	0.10
VEGF	Vascular endothelial growth factor	rs2010963	GG	200	1 (reference)
			GC	196	1.17 (0.87 to 1.58)	0.30
			CC	59	1.01 (0.65 to 1.58)	0.96
VEGF	Vascular endothelial growth factor	rs3025039	CC	344	1 (reference)
			TC	102	0.95 (0.68 to 1.33)	0.77
			TT	10	1.20 (0.49 to 2.92)	0.69
VEGF	Vascular endothelial growth factor	rs699947	CC	124	1 (reference)
			CA	226	1.00 (0.72 to 1.40)	0.99
			AA	100	1.01 (0.68 to 1.50)	0.98

AVF, arteriovenous fistula; SNP, single nucleotide polymorphism; HR, hazard ratio; CI confidence interval.