Table 2.
Summarizes the differences in Th1 and Th2 activated Ag specific Treg and nTreg.
| Gene expression | nTreg | Subclasses of Ag specific CD4+CD25+ T regulatory cells |
|||
|---|---|---|---|---|---|
| Th1 induced |
Th2 induced |
||||
| Ts1 | Th1-like Treg | Ts2 | Th2-like Treg | ||
| IFNGR | + | +++ | ++ | − | ? |
| IL-12Rβ2 | − | ++ | +++ | − | ? |
| IL-5Rα | − | − | − | +++ | ? |
| IL-4Rα | − | ++ | ? | ++ | ? |
| IL-2 | − | − | − | − | − |
| IFN-γ | +/++ | − | +++ | +++ | ? |
| IL-4 | ++ | ++ | ? | ++ | ++ |
| IL-5 | − | ++ | ++ | − | ++ |
| IL-10 | ++ | ++ | ? | ++ | + |
| TGF-β | ++ | ++ | ++ | ++ | ? |
| FoxP3 | +++ | +++ | +++ | +++ | +++ |
| T-bet | − | − | ++ | − | ? |
| GATA3 | − | − | − | − | ? |
| IRF4 | ? | ? | ? | ? | +++ |
| STAT1 | − | ? | ++ | ? | ? |
| Chemokine ligand | CCR4 | ? | CXCR3 | ? | CCR8 |
| Receptors | CCR7 | ||||