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Hydrophobic dimensions of transmembrane domains. (a) Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC) (3EAM) (5) displaying a substantial lipid annulus along with an appropriate hydrophobic thickness. (b) P2X4 receptor (4DW1) (35) with a thin hydrophobic dimension resulting from kinked and highly tilted helices. (c) Surface representation of 4DW1 highlighting the significant opening from the hydrophobic environment into the channel pore.
