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Weak hydrophobic environments in crystal lattices. (a) Rhomboid protease monomers (2IC8) (98) surrounded by detergent and water molecules (carbon, green spheres; oxygen, red spheres). (b) Leukotriene C4 synthase (2UUH) (60) displaying water molecules throughout the surface of the structure. (c) PepTSo (2XUT) (68), with cavities showing poor packing of the last two helices with the rest of the transmembrane domain.
