Table 2.
Outcomes According to RUNX1 Mutation Status in Primary Cytogenetically Normal Acute Myeloid Leukemia
| End Point | RUNX1 Mutated | RUNX1 Wild Type | P* | OR† | 95% CI | HR‡ | 95% CI |
|---|---|---|---|---|---|---|---|
| All patients (N = 392) | |||||||
| No. of patients | 49 | 343 | |||||
| CR | < .001 | 0.27 | 0.14 to 0.49 | ||||
| No. of Patients | 23 | 264 | |||||
| % | 47 | 77 | |||||
| Disease-free survival | < .001 | 2.43 | 1.57 to 3.76 | ||||
| Median, years | 0.6 | 1.1 | |||||
| Disease free at 5 years, % | 0 | 28 | |||||
| 95% CI | — | 23 to 33 | |||||
| Overall survival | < .001 | 2.32 | 1.69 to 3.18 | ||||
| Median, years | 0.9 | 1.4 | |||||
| Alive at 5 years, % | 2 | 30 | |||||
| 95% CI | 0 to 9 | 25 to 35 | |||||
| Event-free survival | < .001 | 2.41 | 1.76 to 3.28 | ||||
| Median, years | 0.2 | 0.8 | |||||
| Event free at 5 years, % | 0 | 22 | |||||
| 95% CI | — | 18 to 26 | |||||
| Younger patients (n = 173) | |||||||
| No. of patients | 14 | 159 | |||||
| CR | .005 | 0.19 | 0.06 to 0.58 | ||||
| No. of Patients | 7 | 134 | |||||
| % | 50 | 84 | |||||
| Disease-free survival | .06 | 2.09 | 0.96 to 4.54 | ||||
| Median, years | 1.2 | 1.9 | |||||
| Disease free at 5 years, % | 0 | 42 | |||||
| 95% CI | — | 33 to 50 | |||||
| Overall survival | .003 | 2.34 | 1.30 to 4.20 | ||||
| Median, years | 1.1 | 2.8 | |||||
| Alive at 5 years, % | 7 | 47 | |||||
| 95% CI | 0 to 28 | 39 to 54 | |||||
| Event-free survival | < .001 | 2.56 | 1.46 to 4.49 | ||||
| Median, years | 0.3 | 1.1 | |||||
| Event free at 5 years, % | 0 | 36 | |||||
| 95% CI | — | 28 to 43 | |||||
| Older patients (n = 219) | |||||||
| No. of patients | 35 | 184 | |||||
| CR | .006 | 0.35 | 0.17 to 0.73 | ||||
| No. of Patients | 16 | 130 | |||||
| % | 46 | 71 | |||||
| Disease-free survival | < .001 | 2.61 | 1.52 to 4.50 | ||||
| Median, years | 0.5 | 0.9 | |||||
| Disease free at 3 years, % | 0 | 18 | |||||
| 95% CI | — | 12 to 25 | |||||
| Overall survival | < .001 | 2.25 | 1.53 to 3.30 | ||||
| Median, years | 0.8 | 1.3 | |||||
| Alive at 3 years, % | 0 | 22 | |||||
| 95% CI | — | 16 to 28 | |||||
| Event-free survival | < .001 | 2.17 | 1.49 to 3.18 | ||||
| Median, years | 0.2 | 0.7 | |||||
| Event free at 3 years, % | 0 | 13 | |||||
| 95% CI | — | 8 to 18 |
Abbreviations: CR, complete remission; HR, hazard ratio; OR, odds ratio.
*
P value is from Fisher's exact test for CR rate and from the log-rank test for time-to-event end points.
†
An OR of < 1 or > 1 means a lower or higher CR rate, respectively, for RUNX1-mutated patients compared with RUNX1 wild-type patients.
‡
An HR of > 1 or < 1 corresponds to a higher or lower risk of an event, respectively, for RUNX1-mutated patients compared with RUNX1 wild-type patients.