Table 3.
Multivariable Analysis of Outcome According to the RUNX1 Mutation Status in All Patients (N = 392) With Primary Cytogenetically Normal Acute Myeloid Leukemia
| Variable | Complete Remission |
Disease-Free Survival |
Overall Survival |
Event-Free Survival |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| RUNX1: mutated v wild type | 0.25 | 0.13 to 0.47 | < .001 | 2.34 | 1.49 to 3.66 | < .001 | 1.65* | 1.13 to 2.42 | < .001 | 2.27 | 1.65 to 3.12 | < .001 |
| IDH2: mutated v wild type | 0.55 | 0.30 to 0.98 | .04 | — | — | — | — | — | — | — | — | — |
| FLT3-ITD: present v absent | — | — | — | 2.50* | 1.83 to 3.42 | < .001 | 1.56 | 1.22 to 1.99 | < .001 | 1.57 | 1.27 to 1.95 | < .001 |
| WT1: mutated v wild type | — | — | — | — | — | — | 1.99 | 1.39 to 2.84 | < .001 | 1.44 | 1.02 to 2.01 | .04 |
| WBC: continuous, 50-unit increase | 0.74 | 0.60 to 0.91 | .004 | 1.17 | 1.03 to 1.32 | .02 | 1.10 | 1.01 to 1.19 | .02 | 1.13 | 1.04 to 1.23 | .006 |
| Age group: ≥ 60 v < 60 years | 0.55 | 0.33 to 0.91 | .02 | 2.19 | 1.67 to 2.88 | < .001 | 2.46 | 1.93 to 3.15 | < .001 | 1.80 | 1.46 to 2.22 | < .001 |
NOTE. An OR of > 1 or < 1 corresponds to a higher or lower odds, respectively, of achieving a complete remission for higher values of continuous variables and the first level listed of a dichotomous variable. For time-to-event end points, an HR of > 1 or < 1 corresponds to a higher or lower risk, respectively, for higher values of continuous variables and the first level listed of a dichotomous variable. Variables were considered for inclusion in the multivariable models if they had a univariable P < .20. See Data Supplement for a full list of variables evaluated in univariable analysis. Variables with insufficient overlap with RUNX1 mutations could not be evaluated by multivariable models investigating the impact of RUNX1 mutations. These were NPM1, CEBPA, and ASXL1 mutations, MLL partial tandem duplication, and the European LeukemiaNet Genetic Groups. On the basis of univariable analyses, variables considered in the model for complete remission were RUNX1 mutations, WT1 mutations, IDH2 mutations, hemoglobin, platelet count, WBC, and age group (≥ 60 v < 60 years). Variables considered in the model for disease-free and overall survival were RUNX1 mutations, presence of FLT3-ITD, WT1 mutations, WBC, and age group (≥ 60 v < 60 years).
Abbreviations: HR, hazard ratio; ITD, internal tandem duplication; OR, odds ratio.
This variable did not meet the proportional hazards assumption. The P value corresponds to the Wald statistic of a 2-df test evaluating whether the coefficients for the variable and an artificial time-dependent covariate were equal to 0, to account for nonproportionality. The HR estimate is provided at 6 months.