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. 2012 Jul 30;30(25):3119–3126. doi: 10.1200/JCO.2012.42.2444

Table 3.

Grade 3 or 4 Toxicities During Chemotherapy and RIT

Toxicity R-CHOP
RIT
Grade 3
Grade 4
Grade 3
Grade 4
No. % No. % No. % No. %
Hemoglobin 1 2
Leukocytes 8 14 10 18 9 17
Lymphopenia 11 19 6 11 18 35 4 8
Neutrophils 7 12 20 35 17 33 11 21
Platelets 1 2 2 4 8 15 16 31
Fatigue 1 2
Diarrhea without previous colostomy 2 4
Muco/stomatitis (symptom), oral cavity 1 2
Febrile neutropenia 2 4 1 2
Infection with grade 3-4 neutropenia, colon 1 2
Infection with grade 0-2 neutropenia, lung 1 2
Hypocalcemia 1 2
Hyperglycemia 3 5 1 2
Hypoglycemia 1 2
Hyponatremia 5 9
Hyperuricemia 1 2
Neuropathy, sensory 2 4
Syncope 1 2
Dyspnea 2 4
Hypoxia 1 2
Worst degree 18 32 22 39 21 40 20 38

Abbreviations: R-CHOP, rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone; RIT, radioimmunotherapy.