Table 3.
Multivariable analysis for SNPs and prostate cancer outcomes. Each SNP is individually assessed in separate multivariable models, controlling for age at prostate cancer diagnosis, PSA at diagnosis, clinical stage, and biopsy Gleason grade. Shown are SNPs with univariate associations at p<0.05 by the “2 degree of freedom test”.
| SNP | Number of patients |
Biochemical Recurrence N=351 |
Clinical Metastases N=146 |
Prostate Cancer Specific Death N=91 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | ||
| rs10486567 | 635 | 1.29 | 1.00, 1.65 | 0.046 | 1.42 | 0.96, 2.10 | 0.083 | 1.1 | 0.66, 1.82 | 0.7 |
| rs4962416 | 628 | 1.08 | 0.84, 1.39 | 0.5 | 0.87 | 0.58, 1.29 | 0.5 | 0.85 | 0.50, 1.45 | 0.6 |
| rs7920517 | 631 | 1.53 | 1.17, 2.01 | 0.002 | 1.11 | 0.73, 1.68 | 0.6 | 1.06 | 0.61, 1.84 | 0.8 |
| rs7931342 | 632 | 1.03 | 0.80, 1.32 | 0.8 | 2.01 | 1.35, 3.00 | 0.0006 | 1.81 | 1.07, 3.05 | 0.027 |
| rs10896449 | 649 | 1.01 | 0.79, 1.28 | 1 | 1.88 | 1.28, 2.77 | 0.001 | 1.83 | 1.10, 3.04 | 0.021 |
| rs2735839 | 643 | 0.88 | 0.67, 1.17 | 0.4 | 1.26 | 0.84, 1.87 | 0.3 | 2.22 | 1.35, 3.66 | 0.002 |
| rs7008482 | 617 | 0.85 | 0.66, 1.09 | 0.19 | 0.87 | 0.59, 1.28 | 0.5 | 1 | 0.60, 1.65 | 1 |
1
The first p-value shown for each SNP was determined by a “2 degree of freedom test” for a global difference across genotypes; the second p-value shown was determined by a log-additive (linear trend) model