Table A1.
Causes of Death Observed on Protocol S0016 by Treatment Arm
| Causes of Death | CHOP-R | CHOP-RIT |
|---|---|---|
| Relapsed lymphoma | 22 | 28 |
| Acute myeloid leukemia | 0 | 2 |
| Pancreatic cancer | 1 | 1 |
| Rectal cancer | 1 | 0 |
| Gastric cancer | 0 | 1 |
| Bladder cancer | 0 | 1 |
| Lung cancer | 0 | 1 |
| Stroke | 1 | 0 |
| Infection | 1 | 1 |
| Pulmonary hypertension | 0 | 1 |
| Perforated gastric ulcer | 0 | 1* |
| Drug overdose | 0 | 1 |
| Unknown | 0 | 2 |
| Total | 26 | 40 |
Abbreviations: CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; CHOP-R, cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab; CHOP-RIT, cyclophosphamide, doxorubicin, vincristine, prednisone with tositumomab/iodine I-131 tositumomab radioimmunotherapy.
*
One patient randomly assigned to the CHOP-RIT arm developed a gastric ulcer that perforated while receiving CHOP chemotherapy (attributed to prednisone). He declined further protocol therapy, never received 131I-tositumomab, and eventually died of apparent inanition related to the perforated ulcer.